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Calibration curves of Glu and GSH were made with standards, and the concentration of GSH was calculated by internal-standard method with 13 C 2 - 15 N-GSH as internal standard, while the concentration of Glu was calculated by external-standard method

doi: 10.1038/cdd.2015.93

Studies have shown that Pip6a-PMO effectively rescues the disease phenotype and improves the survival rate of severe SMA mice, showing strong efficacy in the central nervous system and peripheral tissues